More interestingly, in head and neck squamous cell carcinomas (HNSCC), Kleszcz et al. found that PORCN inhibitors not only effectively induce tumor cell apoptosis but also inhibit their migration ability, and in many targets of Wnt pathway, PORCN and CBP are the most significant targets for tumor inhibition [30]. Here, PORCN is linked to head and neck squamous cell carcinoma.