Abnormality of signal transduction pathway is an important step in the occurrence and development of tumor, and the PI3K/Akt/mTOR signaling pathway is closely related to a variety of human tumors, playing an important role in the proliferation, survival, resistance to apoptosis, angiogenesis and metastasis of tumor cells, and resistance to radiotherapy and chemotherapy of the cells. The gene discussed is AKT1; the disease is neoplasm.