This study was carried out 15 years ago and thereby represents the AF ablation routine of that time: nonirrigated focal RF lesions were placed around or inside the PVs, vitamin K antagonist was interrupted using low molecular weight heparin bridging before the procedure, and intraprocedural heparin applied according to activated partial thromboplastin time (aPTI). The gene discussed is F3; the disease is atrial fibrillation.