On the contrary, treatment of diabetic rats with FUC ameliorated the hepatorenal toxic effects of DM and/or AFB1 as evidenced by reduced blood glucose levels, activities of serum AST, ALT, and ALP, and serum levels of urea, creatinine, 8-OHDG, IL-1B, IL-6, and TNF-α. The gene discussed is TNF; the disease is diabetes mellitus.