In contrast, they observed that in wet AMD or choroidal neovascularization (CNV), choriocapillaris loss preceded RPE atrophy, implicating the choriocapillaris as the focus of injury in wet AMD, which in turn could induce hypoxia in the adjacent RPE, upregulating vascular endothelial growth factor (VEGF), and promoting CNV [9]. This evidence concerns the gene VEGFA and Atrophy.