In contrast, they observed that in wet AMD or choroidal neovascularization (CNV), choriocapillaris loss preceded RPE atrophy, implicating the choriocapillaris as the focus of injury in wet AMD, which in turn could induce hypoxia in the adjacent RPE, upregulating vascular endothelial growth factor (VEGF), and promoting CNV [9]. The gene discussed is VEGFA; the disease is wet macular degeneration.