CD226 and myocardial infarction: Here, we demonstrate for the first time that CD226 expression increased in the infarcted heart following MI, and CD226 deletion modulates macrophages activation status toward a reparative profile in the ischemic heart, while restraining inflammatory monocytes mobilization from the spleen and peripheral blood, leading to reparative collagen deposition and angiogenesis, contributing to infarct healing.