The malignant features of TNBC is proposed to be mediated by breast cancer stem cells (BCSCs) 5-7, for which the current commonly used markers are CD24-CD44+8-10 and aldehyde dehydrogenase (ALDH) 11-13, with CD24-CD44+ labeling the Mesenchymal-like CSCs and ALDH+ defining the Epithelial-like counterpart 14. This evidence concerns the gene CD44 and breast cancer.