ERBB2 and breast carcinoma: Transcriptome profiling according to the intrinsic molecular portraits of breast cancer has identified several major subcategories, such as Luminal, HER2+ and Triple-negative 2, of which Triple-negative Breast Cancer (TNBC) is a heterogenous and refractory subtype, featured by enhanced chemoresistance, relapse, and metastasis 3, 4.