The IKKε expression levels in cancer tissues were lightly associated with advanced cancer stage (Figure 5 C), and the IKKε expression levels in cancer tissues with lymph node metastasis (N1 and N2 stage) were significantly higher than in those without metastasis (N0 stage) (Figure 5 D). The gene discussed is IKBKE; the disease is metastatic malignant neoplasm in the lymph nodes.