Consistently, lower invadopodia formation ability was observed in SW480 CRC cells when compared to HCT116 CRC cells (15% vs. ~80%) (Figure 1 A and E).Then we overexpressed Myc-DDK-tagged wild-type (WT) IKKε or kinase-dead IKKε mutant (K38A) 18 in SW480 cells (Figure S1 C). The gene discussed is MYC; the disease is colorectal carcinoma.