STAT3 and non-small cell lung carcinoma: Our recent study showed that depriving AKR1C1 of its reductase activities (by utilizing 5-BPSA or reductase activity-loss mutants) had little effect on cell motility and STAT3 activation, indicating that the canonical enzymatic activities are dispensable for AKR1C1 to promote NSCLC metastasis 10.