Our recent study showed that depriving AKR1C1 of its reductase activities (by utilizing 5-BPSA or reductase activity-loss mutants) had little effect on cell motility and STAT3 activation, indicating that the canonical enzymatic activities are dispensable for AKR1C1 to promote NSCLC metastasis 10. Here, AKR1C1 is linked to non-small cell lung carcinoma.