More importantly, TCGA database was utilized to analyze the relationship between SIRT2 expression level and Overall Survival (OS) in AKR1C1-highly-expressed (AKR1C1high) and AKR1C1-lowly-expressed (AKR1C1low) NSCLC patients, respectively. The gene discussed is AKR1C1; the disease is non-small cell lung carcinoma.