AKR1C1 and non-small cell lung carcinoma: In addition, the metastasis-driving acetylation of AKR1C1 is not necessary for its enzymatic activity, further highlight the advantage of the acetylation-modulation as a promising intervention strategy for NSCLC metastasis, since the deprivation of acetylation of AKR1C1 would impose no effect on its catalytic activity which is necessary for the physiology function.