Highlighting the importance of these events, formation of the CDCP1/Src/PKCδ complex is accompanied by further cancer promoting signal transduction including via the kinase FAK during loss of cell adhesion 32, the cell-matrix adhesion protein β1 integrin during vascular metastasis 13, the receptor tyrosine kinase HER2 in therapy resistant breast cancer 16 and the kinase Akt in cancer cell survival 11, 12, 26, 33. Here, ERBB2 is linked to breast cancer.