EGFR and lung adenocarcinoma: Metabolic syndrome also has been linked to the development of lung adenocarcinoma, especially in never-smokers, as genome-wide association studies (GWASs) have demonstrated that EGFR, VTL1A, TNFRSF10C, C3ORF21 and hyper-methylations of TNFSF10C, BHLHB5 and BOLL are involved in both pathways [13, 14].