A candidate gene study published in 2017 employed germline sequence data from 555 lung adenocarcinoma cases from The Cancer Genome Atlas to evaluate possible risks associated with the ATM serine/threonine kinase gene (ATM), the BRCA2 DNA repair-associated gene (BRCA2), the checkpoint kinase 2 gene (CHEK2), EGFR, the parkin RBR E3 ubiquitin protein ligase gene (PARK2), the telomerase reverse transcriptase gene (TERT), the tumour protein p53 gene (TP53) and the YES-associated protein 1 gene (YAP1). Here, CHEK2 is linked to lung adenocarcinoma.