CHRNA5 and cancer: Three GWASs for lung cancer [from the International Agency for Research on Cancer (IARC), MD Anderson Cancer Center, and deCODE Genetics], published in 2008, identified the same locus in chromosome region 15q25, an area that includes a cluster of nicotinic acetylcholine receptor genes (CHRNA3, CHRNA5 and CHRNB4) and is associated strongly with lung cancer [34–36].