An analysis based on the histological type of cancer revealed significant associations for 25 variants in the NSCLC group, eight of which (CHRNA5 rs16969968, CLPTM1L rs402710, CYP2E1 rs6413432, ERCC1 rs11615, FGFR4 rs351855, HYKK rs931794, MIR146A rs2910164 and TERT rs2736098) demonstrated strong cumulative epidemiological evidence. This evidence concerns the gene CHRNA5 and cancer.