The PI3K-Akt, MAPK, Ras, FoxO, HIF-1, Toll-like receptor, NF-kappa B, and VEGF pathways are crucial for the functional modulation of the hematopoietic system; further, their aberrant regulation may contribute to HD development [111, 123, 139–163]. The gene discussed is AKT1; the disease is Huntington disease.