AKT1 and gastric cancer: Additionally, although Kv11.1 was not detected in the normal stomach, Kv11.1 expression was upregulated in GC tissues [32], and Kv11.1 has been shown to enhance the proliferation and tumorigenesis of GC both in vitro and in vivo and modulate vascular endothelial growth factor 1 (VEGF-1) secretion through an AKT-dependent pathway (Figure 2) [117, 118].