PDE4A and asthma: Regardless of the wide variety and associations of antiasthmatic medicines and their ability to promote the asthma symptoms control and to reduce the asthma episodes and hospital admissions, the antiasthmatic drugs present several side effects, including nausea, headaches, and convulsions (xanthine class) [3, 30], cardiovascular effects (β-adrenergic receptors antagonists) [20], vomiting (PDE4 inhibitors drugs) [34–36], osteoporosis, myopathies, adrenal suppression, and metabolic disturbs, compromising the patients' growth (corticosteroids) [30, 35, 37, 38].