Additionally, further validation data from TCGA and GEO datasets (OS: n = 1408 CRC patients and DFS: 1367 CRC patients) demonstrated that SOX2 expression was significantly correlated with worse OS (HR = 1.35, P=0.004) and DFS (HR = 1.30, P=0.02). This evidence concerns the gene SOX2 and colorectal carcinoma.