GO and KEGG analyses showed that SOX2 involved in cell-cell junction, focal adhesion, extracellular matrix- (ECM-) receptor interaction, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity, semaphorin receptor activity, MAP kinase activity, mitogen-activated protein kinase binding, transmembrane receptor protein kinase activity, etc. in CRC (Figure 5), and these pathways are closely associated with cancer development. This evidence concerns the gene SOX2 and colorectal carcinoma.