Additionally, the functional analysis showed that SOX2 involved in cell-cell junction, focal adhesion, extracellular matrix- (ECM-) receptor interaction, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity, semaphorin receptor activity, mitogen−activated protein kinase binding, transmembrane receptor protein kinase activity, MAP kinase activity, etc., which further suggested that SOX2 may be closely linked with CRC prognosis. This evidence concerns the gene SOX2 and colorectal carcinoma.