GO and KEGG analyses showed that SOX2 involved in cell-cell junction, focal adhesion, extracellular matrix- (ECM-) receptor interaction, transmembrane receptor protein tyrosine kinase activity, transmembrane-ephrin receptor activity, semaphorin receptor activity, MAP kinase activity, mitogen-activated protein kinase binding, transmembrane receptor protein kinase activity, etc. in CRC (Figure 5), and these pathways are closely associated with cancer development. The gene discussed is WNK2; the disease is cancer.