On the other hand, in agreement with the current study, paeonol decreased the TLR4/NF-κB/TNF-α/IL-6 inflammatory signaling pathway in lipopolysaccharide-induced acute lung injury [55] and IL-1β-induced human fibroblast-like synoviocyte rheumatoid arthritis [56]. This evidence concerns the gene IL1B and rheumatoid arthritis.