In this study, we analyzed CD19+CD24hiCD38hi B cells from peripheral blood of PBC patients to investigate the frequency, proliferative capacity and cytokine production of circulating CD19+CD24hiCD38hi B cells, and the regulatory capacity of this B cell subset in PBC, in order to explore the role of CD19+CD24hiCD38hi B cells in the pathogenesis of PBC. The gene discussed is CD19; the disease is primary biliary cholangitis.