Abdominal adipocytes are more active as endocrine cells than adipocytes of the lower portion of the body, which define gynoid obesity: they are more sensitive to catecholamines and less to insulin, with the end result of a hyperinsulinemia compensatory with low-grade inflammation, altered lipid profile, increased production of androgens and low levels of SHBG, which overall favor anovulation. The gene discussed is SHBG; the disease is Hyperinsulinemia.