Moreover, interferon-γ produced by tumor-infiltrating T cells downregulates the expression of SLC3A2 and SLC7A11, two subunits of the glutamate–cystine antiporter system xc−, impairs the uptake of cystine by tumor cells, and as a consequence, kills cancer cells through the induction of ferroptosis [144], indicating that targeting ferroptosis-associated metabolism in tumors may improve the efficacy of cancer immunotherapy. This evidence concerns the gene SLC3A2 and cancer.