Similarly, increased survival was previously obtained by injecting intraperitoneally a plasmid encoding for IL4 in mice bearing an ascitic form of the C26 tumour.34 The effectiveness of IL4 administration in C26 hosts relies, partially at least, on the promotion of protein synthesis, as shown by puromycin incorporation and by sustained phosphorylation levels of Akt and p70. Here, AKT1 is linked to neoplasm.