Our data comprehensively reveal that the G allele of rs907187, located in promoter region, was associated with reduced activity of the dual‐luciferase in a promoter reporter, with decreased PARP1 mRNA and protein expression in a panel of NB cell lines, and, most importantly, with response to induction therapy in our cohort of NB Italian patients. The gene discussed is PARP1; the disease is neuroblastoma.