CBX4 and Cowden disease: Patients with active CD showed a differentiated chromatin regulation with a clear upregulation of bromodomain containing 7 (BRD7), inhibitor of growth family member 4 (ING4), and methyl CpG binding protein 2 (MECP2), but decreased expression of chromobox homolog 4 and 5 (CBX4, CBX5), chromodomain helicase DNA binding protein 3, 6, and 7 (CHD3, CHD6, CHD7) (Supplemental Fig. 2).