We also observed elevated expression of a number of cancer-associated genes that have been reported to influence the proliferative advantage and the survival of leukaemic cells and genes that were reported to be part of the FLT3-ITD molecular signature, such as CRNDE, CLU, CTSG, IGFBP2, CPA3 and PRDM1634,35. This evidence concerns the gene IGFBP2 and cancer.