SIM2 and Alzheimer disease: For example, genes dysregulated upon short-term stress (on day 3) were linked to cardiovascular diseases (ACTA2), tumor processes (SIM2, POU6F2, ADAMTS12), inflammation and responses to microbes (PALM3, FLG2), reaction to oxidative stress (THSD4), and Alzheimer’s disease (COBL); and genes dysregulated after long-term stress exposure (on day 14) included cardiomyopathies (TNNI3), oxidative stress (CTSE) and antiviral properties (IFIT1b), stress responses (GRIA1), and in neurobehavioral disorders (SLC6A2).