However, as we have shown here, (i) the mild course of disease in NKWT mice correlated with the accumulation c-FLIP-dependent Ly49C+ cNK, (ii) αAsialo-GM-mediated cNK depletion aggravated disease in B6 mice and, above of all, cNK-deficient NKΔEomes mice were by far more sensitive to DSS-induced colitis as compared to controls. Here, CFLAR is linked to colitis.