Similarly, B38-CAP treatment significantly suppressed the increased expression of mRNA associated with cardiac hypertrophy, such as ANF (atrial natriuretic factor), BNP (brain natriuretic peptide), and β-myhc (β-myosin heavy chain, Myh7) in the TAC mice (Fig. 5c–e). The gene discussed is NPPB; the disease is cardiac hypertrophy.