Nevertheless, there was a strong increase in the percentage of cells that expressed CRTAM, EOMES, and T-bet within the CD4+CD44hi T cells in HDAC1cKO-HDAC2HET mice (Figure 6, E and F), suggesting enhanced induction of CD4+ CTL features in HDAC1cKO-HDAC2HET Th cells upon infection. The gene discussed is CRTAM; the disease is infection.