In the current study, we investigated the effect on NSCLC development of miR-144 shuttled from the BMMSC exosomes, finding that delivery of miR-144 via BMMSC-derived exosomes could downregulate CCNE1 and CCNE2 expression, thus attenuating NSCLC cell proliferation, colony formation, and cell cycle progression. Here, CCNE1 is linked to non-small cell lung carcinoma.