The observation of motor deficits in GluA2+/ECS(G) mice was not wholly unexpected, not only due to these deficits previously being reported in GluA2 Q/R site editing deficient mice [38] (including in ADAR2 knockdown mice, which also have motor neuron degeneration [83, 84]), but also because of well-established evidence of GluA2 Q/R site editing deficiencies in the spinal motor neurons of sporadic ALS patients [85]. The gene discussed is GRIA2; the disease is amyotrophic lateral sclerosis.