PRTN3 and anti-neutrophil cytoplasmic antibody-associated vasculitis: In a study conducted by Jones et al., (2017) On AAV patients (ANCA-associated vasculitis) evaluated the role of prednisolone on the DNA methylation pattern on active and inactive samples and showed that median methylation in PRTN3 promoter is independent of GC treatment and is active in patients suffering from the disease.