Since prednisolone, by changing the expression of BCL-2 family of proteins, induces apoptosis in leukemia cells (Ghasemi et al., 2018), the induction of apoptosis and changes in the expression of BAX pre-apoptotic genes and anti-apoptosis BCL2 by changing methylation levels of Transcription Start Cite, we have tried, in this study, to find out whether the promoter of these genes occurs by reducing the methylation (hypo) of the BAX gene and increasing the methylation of the BCL2 gene or not. Here, BCL2 is linked to leukemia.