BRCA1 and ovarian cancer: Defective DNA double-strand repair is a characteristic of germline mutations in BRCA1 and BRCA2 genes in all cells expressing them (Mehrgou and Akouchekian, 2016).They are also classified as pathogenic variants or deleterious mutations that predispose to familial breast and or ovarian cancer (Felix et al., 2018; McCartan and Chatterjee, 2018).