On the contrary, a very recent study by (Abou-El-Naga et al., 2018) found a higher frequency of BRCA1 5382insC among BC patients (11.6%) relative to BRCA1 185delAg (2.3%) but they also found a higher frequency of BRCA1 5382insC mutation among unrelated controls (49.5%) and first-degree relatives of mutation carriers (6.3%), using multiplex-PCR technique. This evidence concerns the gene BRCA1 and breast cancer.