Kyrodimou et al., (2012) read the expression of E - cadherin and Desmoglein -3 in oral leukoplakia and oral squamous cell carcinoma using immunohistochemistry and concluded that alterations in the expression of E - cadherin and Desmoglein - 3 contributes to the malignant transformation of dysplasia and aggressiveness of the caner. This evidence concerns the gene CDH1 and Oral leukoplakia.