Interestingly, the highest rates of cyclin D1 gene amplification are observed in Head and Neck Squamous Cell Carcinoma (HNSCC), especially regarding not LSCC, but also pharyngeal and Oral Squamous Cell Carcinomas (OSCCs) (Niméus et al., 2014). The gene discussed is CCND1; the disease is head and neck squamous cell carcinoma.