CHI3L1 and breast cancer: Lysosomal protein transmembrane 4 beta (LAPTM4B), receptor activator of nuclear factor-kappa b (NF-Kb) ligand (RANKL), osteoprotegerin (OPG), vitamin D (VIT D), chitinase-3-like protein 1 (also known as YKL-40), and sirtuin 1 (SIRT1), have been reported to be upregulated in many human malignancies, including BC (Johansen et al. 2009; Weichhaus et al. 2015; Zhang et al. 2015).