LAPTM4B and Familial prostate cancer: Moreover, other studies have demonstrated that LAPTM4B has been upregulated in many human cancers, such as lung cancer (Tang et al., 2014), gastric cancer (Zhang et al. 2014), and prostate cancer (Zhang et al., 2015), and is known to have a role as a dynamic cancer-associated biomarker that is involved in several biological processes (Kasper et al., 2005).