ACE and neoplasm: Tumor growth and development is inhibited by Angiotensin-Converting Enzyme Inhibitors (ACEIs), which occurs in different ways; including inhibition of enzymes with a role in extracellular matrix deterioration, matrix metalloproteinase (MMP) and etc. Matrix deterioration is entirely under the control of MMPs which is required for differentiation, angiogenesis, adhesion and metastasis with molecular bioactive processing (Lindberg et al., 2003)