Lymphomas that carry MYC and either a BCL2 or a BCL6 translocation (a double-hit lymphoma, DHL) or all three rearrangements (a triple-hit lymphoma, THL) are included in the current WHO classification as a new entity termed “High-grade B cell lymphomas with MYC and BCL2 and BCL6 rearrangements” [150]. This evidence concerns the gene MYC and lymphoma.