As reported here, we believe that the disruption of altered epigenetic regulation with HDAC inhibitors, the blockade of microRNAs function, or the use of BET inhibitors that obstruct scaffold transcriptional activating machinery, are but a few examples of the promising therapeutic strategies that will lead to an improved prognosis of hematological disorders, mostly mediated by the maintenance of MYC at physiological levels. Here, HDAC9 is linked to hematologic disorder.