In MPNST-induced tumours, Jessen et al. could successfully inhibit tumour growth in a NF1-/- S462-TY human MPNST xenograft model when targeting with allosteric MEK inhibitor PD0325901 [15], underlining the putative usage of an additional MEK1/2 inhibitor in vivo. Here, MAP2K1 is linked to malignant peripheral nerve sheath tumor.