As another example, the detection of specific chromosome aberrations, such as t(9;22)(q34;q11.2) for BCR-ABL1, which results in the formation of the Philadelphia (Ph) chromosome, or t(12;21) aberrations of TEL/AML1 gene translocations are used to assign B-ALL patients to specific targeted therapies [67]. The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.