In B-CLL patients, an unsupervised hierarchical bicluster evaluation recognized three diverse clusters (CLs) of extremely interrelated but differentially produced cytokines: CL1 (IL-15, IL-12, IFN, CXCL9, CXCL10, CXCL11, CCL3, CCL4, and CCL19), CL2 (IL-6, IL-8, GM-CSF, and TNF), and CL3 (IFN, IL-1, IL-4, IL-15, and IL-17). Here, CSF2 is linked to B-cell chronic lymphocytic leukemia.