MMP3 and Parkinson disease: Indeed, it has been shown that, upon stress conditions, inducible and activated MMP3 in dopaminergic cells digested α-synuclein in dopaminergic neurons, playing a pivotal role in the progression of Parkinson’s disease through the modulation in the aggregation of C-terminal truncated α-synuclein, Lewy body formation, and neurotoxicity [47].