In addition to SCr, several urine biomarkers have emerged as more sensitive indicators for early detection of AKI, such as urine levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), activin A, and insulin-like growth factor-binding protein 7 (IGFBP-7) [27,28,29,30]. The gene discussed is LCN2; the disease is acute kidney injury.