Table 3 shows the frequency distribution between CRC cases and controls of HLA alleles (top ten associations sorted by p-value). In the unadjusted regression model, some HLA alleles showed a significant association with CRC. Specifically, HLA-C*07:01 allele frequency was decreased in patients with CRC compared to healthy controls (p < 0.05, OR = 0.82, 95% CI 0.69–0.98), while HLA-C*12:03 and HLA DRB1*11:01 alleles was increased in CRC compared to controls (p < 0.05, OR = 1.30, 95% CI 1.01-1.67; and p < 0.05, OR = 1.32, 95% CI 1.06-1.65, respectively). This evidence concerns the gene HLA-C and colorectal carcinoma.