The C1845A mutation on GRIN2A gene encodes for GluN2AN651K variant at the M2 loop leading to low Mg2+ blockade [51], decrease in Ca2+ permeability both for di-heteromeric and tri-heteromeric NMDARs, and to epileptic encephalopathy with cognitive impairment [52,53]. This evidence concerns the gene GRIN2A and Epileptic encephalopathy.