Several mutations of GRIN2A (encoding the GluN2A subunit) leading to NMDAR gain- or loss-of-function have been associated with different epilepsy-aphasia spectrum (EAS) such as benign epilepsy with centrotemporal spikes (BECTS), the Landau–Kleffner syndrome (LKS) and epileptic encephalopathy with continuous-spike-and-waves-during-slow-wave-sleep (CSWSS) [166,167,168]. This evidence concerns the gene GRIN2A and epilepsy.