Dysfunctional levels of NTs, as well as SNAP-25, Syntaxin-1, Syp, PSD-95, MAGUK, and SHANK proteins, are involved in neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and dementia with Lewy bodies (DLB) [59]. The gene discussed is SHANK2; the disease is Alzheimer disease.