FLT3 and acute myeloid leukemia: In particular, two multi-kinase inhibitors were approved for the treatment of AML carrying gain-of-function mutations in Fms-like tyrosine kinase 3 (FLT3) gene: Midostaurin in combination with conventional induction and consolidation chemotherapy in newly diagnosed patients [2] and gilteritinib monotherapy for relapsed/refractory (R/R) FLT3-mutated patients [3].