The sarcomas TME is also rich with immunosuppressive cytokines including vascular endothelial growth factor (VEGF) that, together with hypoxia-inducible factor-1 α (HIF-1α), inhibits the maturation of dendric cells and promotes M2 macrophages and Treg migration inside the tumor stroma [50,51]. The gene discussed is HIF1A; the disease is neoplasm.