The authors point out that FBP2 decrease leads to the increased glycolytic activity observed in sarcomas, while FBP2 re-expression hinders tumor progression through two mechanisms: i) inhibition of glucose uptake and lactate secretion; ii) restrain mitochondrial biogenesis by repressing c-Myc-dependent transcriptional activity [133]. The gene discussed is FBP2; the disease is neoplasm.