PRAME and neoplasm: In addition, isolated cells can be genetically modified to improve recognition of tumor cells, for example through knock-in of a NBL-specific T cell receptor (TCR) [40,86,87], a chimeric antigen receptor (CAR) [20,88,89,90,91,92,93,94,95], or a bispecific antibody [96,97] against tumor specific targets such as GD2, PRAME, NY-ESO-1, L1-CAM, B7-H3, and mutated ALK.