Similarly, Dahmcke et al. proposed a six gene methylation panel (SALL3, ONECUT2, CCNA1, BCL2, EOMES and VIM) combined with the mutational analysis of TERT and FGFR3, for early detection of BlCa, in urine samples, comparing BlCa patients and patients with gross haematuria [30]. The gene discussed is BCL2; the disease is bladder transitional cell carcinoma.