INT-767 activates the nuclear hormone receptors, farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5 to confer nephroprotection in mice with streptozotocin–induced T1DM and in T2DM db/db mice (lower proteinuria, podocyte injury, mesangial expansion, and tubulointerstitial fibrosis) through recruitment of multiple pathways, including stimulation of AMPK/SIRT1/PGC-1α [183]. The gene discussed is PPARGC1A; the disease is type 1 diabetes mellitus.