PKM and Hyperglycemia: Pyruvate kinase M2 (PKM2) activity was decreased and the PKM2 small-molecule activator TEPP-46 reversed hyperglycemia-induced mitochondrial dysfunction, partially by increasing PGC-1α mRNA in cultured podocytes and in streptozotocin-induced diabetic mice, in whom it reduced albuminuria and diabetic glomerular histological features [186].