PPARGC1A and diabetes mellitus: The selective SIRT1 agonist BT175 increased SIRT1-mediated activation of PGC1-α and protected against high glucose-mediated mitochondrial injury in cultured podocytes while both podocyte-specific SIRT1 overexpression and BT175 decreased diabetes-induced podocytopenia and glomerular oxidative stress in mice [179].