The pre-glioblastoma subtype within isocitrate dehydrogenase 1 (IDH1) mutant gliomas express low BMP4 (Figure 2C) [56], in comparison to early progenitor-like and neuroblastic subtypes, and is associated with a poor patient prognosis (Figure 2D) [54,57]. This evidence concerns the gene BMP4 and central nervous system cancer.